Longevity Platform
Targeting the Hallmarks of Aging
Targeting the
Hallmarks of Aging
Our approach is grounded in cutting-edge aging biology research. We focus on the universally recognized “Hallmarks of Aging” – the cellular and molecular processes that drive aging and age-related diseases:
- Genomic instability
- Telomere attrition
- Epigenetic alterations
- Loss of proteostasis
- Deregulated nutrient sensing
- Mitochondrial dysfunction
- Cellular senescence
- Stem cell exhaustion
- Altered intercellular communication
By targeting these fundamental mechanisms, we develop therapies with the potential to impact multiple age-related conditions, rather than treating diseases in isolation.
Exploring the Biology of Aging to Develop Tomorrow's Therapeutics
Our research is focused on identifying and targeting the fundamental mechanisms of aging. We have developed unique R&D capabilities:
Target Identification
& Validation
We Explore and identify the fundamental mechanisms of aging by Targeting pathways like Mas-related G protein-coupled receptor (MasR), which is part of the renin angiotensinsystem, Peroxisome proliferator-activated receptor pathway and key inflammatory and angiogenic signaling routes, including NF-κB and AP-1 transcription factors.
Technology Assessment
and Lead ID
Expertise across discovery and development with a unique tech-forward approach integrating various drug Modalities:
Small Molecules: Precision-targeted, scalable, orally available
Other technologies: Programmable, tissue-selective, adapted for complex targets
Screening and
Candidate selection
We leverage a unique, dual-method screening approach:
- Focused Screening: selection and testing of compounds based on prior knowledge, literature, and known chemical classes with activity against aging pathways.
- Virtual Screening via AI-Driven Discovery: advanced analytics powered by our partnership with Lynx Analytics to reveal new lead candidates, accelerating the discovery timeline and increasing probability of success.
