JUNE 4, 2025

Biophytis announces its participation in the BIO International Convention from June 16 to 19 Biophytis announces its participation to the BIO International Convention, which will take place this year in Boston, USA, from June 16 to 19, 2025. Edouard Bieth, Chief Strategy Officer at Biophytis, will be present and will take part in numerous meetings throughout the Convention. The goal is to present the Company’s latest developments, particularly regarding its drug candidate BIO101, including its Phase 2 OBA study in obesity. This will also be an opportunity to engage with many international pharmaceutical players and explore potential research or commercialization

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MAY 30, 2025

Information on the Annual Financial Statements Biophytis announces that, due to exceptional circumstances related to technical complications in the audit process, the publication of its 2024 annual financial statements has been postponed. The Company requires additional time to complete the audit and certification of its accounts. As a result, Biophytis will publish its 2024 annual financial statements by the end of June 2025. Accordingly, Biophytis has also decided to postpone the date of its Ordinary General Meeting of shareholders. The convening of this meeting will be carried out in accordance with applicable legal procedures. Biophytis has initiated the necessary steps

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MAY 15, 2025

Biophytis Highlights Innovative Approach to Obesity Treatment During Key ECO 2025 Presentation Biophytis announced its active participation at the 32nd European Congress on Obesity (ECO 2025), held from May 11 to 14 in Malaga, Spain. During this premier international event, which brings together leading experts, clinicians, researchers, and industry stakeholders to discuss the latest advances in obesity research and treatment, Biophytis was selected to deliver an oral presentation. The company’s Clinical Research Lead, Dr Serge Camelo, presented the latest clinical development data from the OBA program with BIO101 (20-hydroxyecdysone), Biophytis’ innovative drug candidate targeting muscle loss and function decline in

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APRIL 25, 2025

Postponement of the publication of the annual financial statements Biophytis announces the postponement of the publication of its annual financial statements for the year ended December 31, 2024. Due to the €2.6 million refinancing operation (announced in the press release dated March 26, 2025), the Company had to focus its efforts on the related discussions and negotiations. As a result, the Company is not able to meet the legal deadline for the publication of its 2024 annual financial statements, set for April 30, 2025. Biophytis is making every effort to finalize and publish its financial statements by the end of

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APRIL 22, 2025

Biophytis targets mobility restoration in patients with obesity Biophytis strentghens its position as one of the leading players in preserving muscle function in patients with obesity treated with GLP-1 therapies. While these treatments are revolutionizing obesity care by delivering significant weight loss, they also induce a concerning loss of muscle mass, which can compromise patients’ mobility, strength, and quality of life. It is now essential to move beyond viewing weight loss purely in quantitative terms and focus instead on the quality of weight loss—meaning the reduction of fat mass while preserving muscle mass and improving functional mobility. The development of

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APRIL 9, 2025

Biophytis Confirms the Launch of the Phase 2 OBA Clinical Trial in Obesity Biophytis confirms the launch of the Phase 2 OBA clinical study in obesity, expected to begin as early as possible in 2025. Following the recent €2.6 million capital increase announced on March 26, 2025, and promising preclinical results presented at the 15th International Conference on Frailty and Sarcopenia in Toulouse, Biophytis will continue the clinical development of BIO101 in obesity. The goal is to evaluate the efficacy and safety of BIO101 in reducing muscle strength loss caused by GLP-1 agonists in patients with obesity. As a reminder,

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MARCH 28, 2025

Biophytis announces the settlement and delivery of its €2.6 million private placement NOT FOR DISTRIBUTION, DIRECTLY OR INDIRECTLY, IN THE UNITED STATES OF AMERICA, CANADA, AUSTRALIA, JAPAN AND SOUTH AFRICA Biophytis announces today the settlement and delivery of its private placement in the amount of €2,599,979.72 (including the issuance premium), carried out through the issuance, without preferential subscription rights, of (i) 4,307,614 new ordinary shares of the Company (the “New Shares”), each accompanied by a share subscription warrant (a “Warrant”) (together with the New Share, the “ABSA”), and (ii) 5,692,308 prepaid subscription warrants (the “Prepaid Warrants”), each also accompanied by

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MARCH 26, 2025

Biophytis announces the successful completion of a €2,6 million private placement Capital increase of a total amount of approximately €2,6 million in gross proceeds by issuing 4,307,614 new shares, each with one share warrant attached, at €0,26 per unit, and 5,692,308 pre-funded warrants, each with one share warrant attached, at €0,25 per pre-funded unit; Gross proceeds include €2 million from Armistice, and approximately €0,6 million from a limited number of other qualified investors. Settlement-delivery of the new shares and share warrants expected on March 28, 2025. NOT FOR DISTRIBUTION, DIRECTLY OR INDIRECTLY, IN THE UNITED STATES OF AMERICA, CANADA, AUSTRALIA,

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MARCH 24, 2025

Biophytis announces new non-clinical data further supporting its mission to pioneer the restoration of mobility in patients with obesity 96% of patients with obesity report experiencing muscle strength impairment, affecting their mobility. New preclinical study results: The combination of BIO101 and GLP-1 induced muscle strength and mobility restoration in animal model. Biophytis announces new preclinical results for its investigational drug BIO101. These results were presented for the first time last week at the 15th International Conference on Frailty and Sarcopenia Research in Toulouse. Key findings on BIO101 in obesity include: In this newly reported preclinical study BIO101, in combination with

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MARCH 17, 2025

Biophytis revolutionizes sarcopenia Biophytis is excited to announce a world premiere: the publication of the Phase 2 clinical trial SARA-INT in the Journal of Cachexia, Sarcopenia and Muscle (JCSM), the key reference journal for research on sarcopenia. Key BIO101 Attributes from the SARA INT Trail include: Promising Efficacy: BIO101 350mg bid demonstrates a clinically meaningful improvement in the 400-meter walk test (400MWT), primary endpoint of the study Excellent Safety: At all doses, BIO101 shows a very good safety profile with no Serious Adverse Events (AE) related to the product Greater Efficacy in high-risk population: Nominally significant treatment effect versus placebo

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